Kallikrein-kinin system in neovascularization.
نویسنده
چکیده
Kinin System in Neovascularization − Kallikrein Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2009 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/ATVBAHA.109.184549 2009;29:617-619 Arterioscler Thromb Vasc Biol. http://atvb.ahajournals.org/content/29/5/617 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Kinin receptor agonism restores hindlimb postischemic neovascularization capacity in diabetic mice.
Limb ischemia is a major complication of thromboembolic diseases. Diabetes worsens prognosis by impairing neovascularization. Genetic or pharmacological inactivation of the kallikrein-kinin system aggravates limb ischemia in nondiabetic animals, whereas angiotensin I-converting enzyme/kininase II inhibition improves outcome. The role of kinins in limb ischemia in the setting of diabetes is not ...
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Hypertension that results in left ventricular (LV) hypertrophy and/or fibrosis can lead to cardiac dysfunction. Spontaneously hypertensive rats (SHR) develop high blood pressure and LV hypertrophy at an early age and are a popular model of human essential hypertension. To investigate the role of the tissue kallikrein-kinin system in cardiac remodeling, an adenovirus containing the human tissue ...
متن کاملRole of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential.
Reduced migratory function of circulating angiogenic progenitor cells (CPCs) has been associated with impaired neovascularization in patients with cardiovascular disease (CVD). Previous findings underline the role of the kallikrein-kinin system in angiogenesis. We now demonstrate the involvement of the kinin B2 receptor (B(2)R) in the recruitment of CPCs to sites of ischemia and in their proang...
متن کاملTissue kallikrein inhibits retinal neovascularization via the cleavage of vascular endothelial growth factor-165.
OBJECTIVE Tissue kallikrein, a widely used vasodilator for the treatment of hypertension and peripheral circulatory disorder, acts by releasing kinin, a potent vasodilator peptide. To identify the role of tissue kallikrein in retinal neovascularization, we investigated the antiangiogenic effect by using an in vitro and in vivo angiogenesis model. METHODS AND RESULTS Tissue kallikrein in vitre...
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ورودعنوان ژورنال:
- Arteriosclerosis, thrombosis, and vascular biology
دوره 29 5 شماره
صفحات -
تاریخ انتشار 2009